Revisiting novel interventions in melanoma

Malignant tumor which that arises from uncontrolled proliferation of melanocytes is melanoma. Its rare in India, compared to other tropical countries. Fair skin populations have higher incidences The relative mortality reduced nearly half with scrupulous use sunscreens - SPF 50 blocks 98% UVB rays. Melanomas are observed more countries like Australia and New Zealand (due actinic rays (UV B rays) light) thus guidelines their ministry health has been published. First line drugs for melanoma unresectable stage III or IV metastatic disease include Pembrolizumab Nivolumab. Studies shown improved overall survival (OS) ipilimumab. Ipilimumab/Nivolumab combination was significantly better than ipilimumab monotherapy. Similarly nivolumab/ipilimumab therapy monotherapy regardless BRAF mutation status. Vemurafenib Dabrafenib (Tyrosine kinase inhibitors) were developed inhibit mutations at V600. Dabrafenib/Trametinib Vemurafenib/Cobimetinib combinations Surgery remains the best option cure localized, invasive melanoma, good rate.